This report constitutes a detailed outline of the findings and recommendations of the consensus conference group, organized according to structural guidelines as defined. Factors in category III included DNA ploidy analysis, microvessel density, epidermal growth factor receptor, transforming growth factor-alpha, bcl-2, pS2, and cathepsin D. Category II factors included c-erbB-2 (Her2-neu), proliferation markers, lymphatic and vascular channel invasion, and p53. Recommendations were based on the following aims: (1) increasing uniformity and completeness of pathologic evaluation of tumor specimens, (2) enhancing the quality of data collected about existing prognostic factors, and (3) improving patient care.įactors ranked in category I included TNM staging information, histologic grade, histologic type, mitotic figure counts, and hormone receptor status. We assessed potential prognostic factors for LRR in a cohort of locally advanced HER2+ patients treated with neoadjuvant chemotherapy. For each factor, detailed recommendations for improvement were made. It’s based on a pathologist’s study of the tumor tissue and any lymph nodes removed during surgery. Ki67 is the most commonly used marker of proliferation in. Pathologic staging is the standard way to stage breast cancer. Prognostic factors in breast cancer with a focus on the role of tumour proliferation. In general, the earlier the stage, the better the prognosis will be. The breast cancer incidence in Vietnam has increased steadily over the last decade from a crude rate of 13.8 per 100,000 women in 2000 to 28.1 per 100,000 women. Factors in categories I and II were considered with respect to variations in methods of analysis, interpretation of findings, reporting of data, and statistical evaluation. Breast cancer stage is the most important factor for prognosis (chance of survival). ![]() A registry analysis of 500 BCLM patients found HR positive breast cancer reduced the risk of death by 33 compared with HR negative breast cancer 7. ![]() ![]() Under the auspices of the College of American Pathologists, a multidisciplinary group of clinicians, pathologists, and statisticians considered prognostic and predictive factors in breast cancer and stratified them into categories reflecting the strength of published evidence.įactors were ranked according to previously established College of American Pathologists categorical rankings: category I, factors proven to be of prognostic import and useful in clinical patient management category II, factors that had been extensively studied biologically and clinically, but whose import remains to be validated in statistically robust studies and category III, all other factors not sufficiently studied to demonstrate their prognostic value. Importantly, molecular subtypes are not only a risk factor for liver metastasis but also a predictor of clinical outcome of BCLM patients.
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